Immune Complexes – Close Encounter of Antigen and Antibody



About > Immune Complexes > product of antibody binding to antigen.

Designer antibody therapy and antibody design for best capture of analytes in the diagnostic laboratory set the stage for antigen-antibody complexes as illimited scenarios of applications.

Interaction of Immune Complexes with cells and complement taps into so far unknown sites and effector systems relevant to human pathology, including, at its very best, the NLRP3 inflammasome system.  Immune Complexes and their receptor lab analytics, including complement system piled up into big data warehouses need to be turned into smart data for the patients – a challenge for primary caretakers cross-examined with this website, In 2019, the four V’s make immune complexes even more thrilling: volume (molecular size), velocity (speed of complex formation between antibody and antigen), variety of information (results from lab tests detecting immune complexes) and value (what does this mean for the patient). Glycation extent of immunoglobulins and whether they are also classified as AGE (advanced glycation end products) in senescence is currently scrutinized.
Fc fragments undergoing sialylation and fucosylation to different extents may change performance of the IgG in immune defense.
Drs Richard D. Cummings of the National Center for Functional Glycomics; USA and Stephan von Gunten of the University of Bern, Switzerland, look at these aspects. To be followed.

Lab test Reference Intervals

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update november 2019 

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