Cytokine Network

Immune complexes impinge on the cytokine network. This elusive system is fraught with difficulty in some diseases and must be sensitive to down-regulatory mechanisms e.g. suppressor of cytokine signaling 3 (SOCS3). SOCS3 overexpression abrogates IL-6-induced activation by immune complexes. Immune complexes suppress Th17 responses through enhancement of IL-10 production but they inhibit IL-1 secretion and inflammasome activation –>  Inflammasomes are signaling complexes that sense inflammatory signals under a great many of conditions, immune complex impingement being one of them